R2R DACs are like mechanical watches.
Cheap ones are garbage, ludicrously expensive ones can be surprisingly accurate, but anyone claiming their Grand Seiko is more accurate than some G-Shock Quartz watch is a clown in my book.
You buy them for their novelty or because you appreciate the craftsmanship that goes into them. Not because they're better at telling the time.
You buy R2R DACs for their novelty or because you appreciate the craftsmanship that goes into them. Not because they're better at reproducing music.
Why do amplifiers from different companies, made with different components, sound the same?
Why do different hammers from different tool companies hit a nail the same way?
The computer does not "know" whether you're streaming audio or memes. Just make sure you have correct drivers, settings and connectivity. Forget any clocks, hifi cables and whatever.